| Data | Casa | Visitante | Resultado |
|---|---|---|---|
| 20-02-25 17:45 | Olimpija Ljubljana | FK Borac | 0:0 |
| 20-02-25 17:45 | Pafos FC | Omonia Nicosia | 2:1 |
| 20-02-25 17:45 | 1. FC Heidenheim 1846 | FC Copenhaga | 1:3a.p. |
| 20-02-25 17:45 | Real Betis Sevilla | KAA Gent | 0:1 |
| 20-02-25 20:00 | Shamrock Rovers | Molde FK | 4:6a.pen. |
| 20-02-25 20:00 | Panathinaikos Atenas | Vikingur Reykjavik | 2:0 |
| 20-02-25 20:00 | APOEL Nicósia | NK Celje | 0:2 |
| 20-02-25 20:00 | Jagiellonia Bialystok | TSC Backa Topola | 3:1 |